Disease Ontology — Data Braids

Disease classification and biological pathway databases for drug target identification and pathway enrichment analysis. All braided on westGate.

MONDO Disease Ontology

Unified disease ontology merging OMIM, Orphanet, EFO, DOID, and NCIt. Disease-gene and disease-phenotype mappings. tideGlass Module 4 base data.

What’s Possible

• Map disease terms to drug targets via ChEMBL bioactivity
• Cross-reference disease-gene associations with NCBI Gene annotations
• Feed tideGlass Module 4 for disease-aware drug repurposing
• Combine with Reactome pathways for disease-specific pathway enrichment

The Braid

sweetGrass braid.create produced a W3C PROV-O JSON-LD attestation:

{
  "@context": "https://www.w3.org/ns/prov#",
  "@id": "urn:braid:mondo-disease-westgate-20260801",
  "prov:wasGeneratedBy": {
    "@type": "prov:Activity",
    "prov:used": "https://mondo.monarchinitiative.org/",
    "prov:wasAssociatedWith": "did:eco:westgate"
  },
  "prov:wasAttributedTo": "did:eco:westgate",
  "prov:generatedAtTime": "2026-08-01T...",
  "eco:license": "CC-BY-4.0",
  "eco:blake3_root": "...",
  "eco:file_count": 2,
  "eco:size_bytes": 107986944
}

Reactome Pathway Database

2,700+ curated biological pathways covering metabolism, signaling, gene expression, transport, and disease. Gold standard for pathway enrichment analysis. tideGlass Module 4 base data.

What’s Possible

• Pathway enrichment for LINCS perturbation signatures
• Drug-pathway impact analysis with ChEMBL
• Combine MONDO disease terms with Reactome pathways for disease-specific therapeutic target identification
• Feed wetSpring systems biology analysis with curated pathway knowledge

The Braid

sweetGrass braid.create produced a W3C PROV-O JSON-LD attestation:

{
  "@context": "https://www.w3.org/ns/prov#",
  "@id": "urn:braid:reactome-westgate-20260801",
  "prov:wasGeneratedBy": {
    "@type": "prov:Activity",
    "prov:used": "https://reactome.org/download-data",
    "prov:wasAssociatedWith": "did:eco:westgate"
  },
  "prov:wasAttributedTo": "did:eco:westgate",
  "prov:generatedAtTime": "2026-08-01T...",
  "eco:license": "CC-BY-4.0",
  "eco:blake3_root": "...",
  "eco:file_count": 3,
  "eco:size_bytes": 100663296
}

See Also

• Cancer Genomics — TCGA Xena (clinical data)
• Gene Expression — LINCS L1000 (perturbation signatures)
• Drug Discovery — ChEMBL (bioactivity)